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PLCO Announcements
PLCO EEMS is temporarily closed.

Please be advised—Due to an administrative transition, PLCO EEMS is currently not accepting proposal or study concept applications. Please continue to check STaRS for updates on when the next round will open.

The National Cancer Institute has issued a new Funding Opportunity Announcement (FOA), Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (PAR-13-036), for soliciting grant applications to utilize the PLCO Biorepository. This FOA supports a wide range of cancer research including, but not limited to, biochemical and genetic analyses of cancer risk, as well as discovery and validation of early detection biomarkers. The proposed research project must involve use of PLCO biospecimens; additionally, it should also take advantage of the unique characteristics of the PLCO biospecimens. Research projects that do not involve the use of PLCO biospecimens will not be supported under this FOA. For more information about this funding opportunity and for how to submit a grant application, please refer to the NIH Guide. Read more….

For Investigators who wish to apply for specimens without funding please follow the PLCO application process that is described below.

PLCO CDAS Announcement

We are proud to announce the launch of the Cancer Data Access System (CDAS). All future requests for PLCO data that do not include biospecimens will be handled through this system. Any requests involving biospecimens will continue to be reviewed and tracked through

Interested investigators can register with CDAS and request access to data from PLCO (and also from NLST). All requests are reviewed by NCI trial leadership. Upon approval, investigators will be granted access to the requested data for a limited period.

CDAS provides extensive documentation for each trial including a summary of the trial, a description of the data collected, and a searchable list of research projects and publications.

Analytic data sets for P,L,C,O and 14 other common sites of interest are available through a standard request. These data sets contain nearly all the study data available for screening, incidence and mortality analyses. Special requests can be made for multiple cancers, other cancers, questionnaire data (SQX, DQX, DHQ), or sensitive data.

Existing projects that have an approved Proposal Application Form (PAF) will not need to re-apply through the CDAS system.

Please send any questions about CDAS or PLCO data to

The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is a large population based randomized trial designed and sponsored by the National Cancer Institute (NCI) to determine the effects of screening on cancer-related mortality and secondary endpoints in men and women aged 55 to 74. The screening component of the trial was completed in 2006. Participants are being followed and additional data will be collected through 2015. Numerous epidemiologic and ancillary studies are also underway to answer related crucial questions.

Learn more about PLCO, how to obtain access to study data and biospecimens, and view additional information by accessing links below. Go to PLCO STaRS to complete and submit all forms and applications for biospecimen requests. Access PLCO STaRS by clicking the login button located on the upper right corner of this page.

If you do not have access to the PLCO STaRS site or have questions, contact the PLCO Helpdesk at

Public use datasets can be found at the Cancer Data Access System (CDAS).

Data & Biospecimen

Propose a Study

Current & Completed Research

How Do I?

Investigators who are interested in learning more about PLCO biospecimens or data can find more information in the following sections:


The following links provide investigators with information on how to submit an application, sample forms, and Etiologic & Early Marker Studies (EEMS) access policies and procedures:


Data Only


Investigators who are interested in ongoing research or published manuscripts will find information in the following links:


Page last updated November 30, 2012